王琛

发布日期:2016-08-31浏览次数:217


  王琛:博导、二级教授。1993年获北京农业大学学士学位,1998年获中科院上海生物化学研究所博士学位,1998-2002年在美国德克萨斯西南医学中心(UT Southwestern Medical Center)进行博士后训练。2002-2016年任中科院上海生命科学研究院生化与细胞所课题组长、博导。曾任中科院分子细胞生物学重点实验室副主任,生化与细胞所学术委员、民盟中科院上海分院副主委、上海市第十三、十四届人大代表,第十一届全国青年委员。20165月起任中国药科大学生命科学与技术学院教授、博导、院长。曾获得科技部“973”和“863”项目,国家基金委“杰出青年基金”、“重点项目”、“中加国际合作项目”、“创新研究群体”、“面上项目”、中科院“百人计划”、“分子细胞卓越中心”等支持。兼任Chemistry of LifeChinese Journal of Cell BiologyActa Biochimica et Biophysica Sinica等期刊编委。


研究工作:

综合运用分子细胞生物学、免疫学和疾病动物模型,聚焦在发现并解析宿主模式识别受体的特异性识别(TLRsRLRscGAS-STING)、细胞信号转导关键通路(NF-kBIRF3)的组成与动态变化、早期免疫应答反应的时空特性,阐释固有免疫与急性炎症相关的分子调控机制。特别关注泛素与类泛素化修饰(UbSUMOISG15NEED8)调控固有免疫和炎症的新功能与新机制,并从天然小分子化合物库中筛选并研究调控相关通路的先导化合物。以第一或通讯作者在NatureCellImmunityNatureImmunologyJournalofCellBiologyPLOSPathogens, CellResearchDevelopmentJournalofImmunologyMolecularandCellularBiologyMolecularBiologyoftheCellJournalofVirologyImmunologyCytokine & GrowthFactorsReview等杂志发表论文50余篇。


代表性论文:

1. Wei Chen, Senlin Li, Huansha Yu, Xing Liu, Lulu Huang, Qiang Wang, Heng Liu, Ye Cui, Yijun Tang, Peng Zhang,Chen Wang*(2016): Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs. PLOS Pathogens. http://dx.doi.org/10.1371/journal.ppat.1005462.

2. YiZhou, RuiGe, RuiWang, FengLiu, YuefengHuang, HengLiu, YanHao, QinZhou*, ChenWang*(2015): UXTpotentiatesangiogenesisbyattenuatingNotchsignalingDevelopment. Vol142(3):1-13.

3.QiangWang, XingLiu, YeCui, YijunTang, WeiChen, SenlinLi, HuanshaYu, YoudongPanChenWang*(2014): TheE3UbiquitinLigaseAMFRandINSIG1BridgetheActivationofTBK1KinasebyModifyingtheAdaptorSTING.Immunity. Vol41(6): 919-933.

4.Yue-fengHuang, HengLiu, Sen-linLi, Yi-junTang, BoWei, Huan-shaYuChenWang*(2014): MAVS-MKK7-JNK2DefinesaNovelApoptoticSignalingPathwayduringViralInfectionPLoSPathogens. Vol10(3): e1004020. doi: 10.1371/journal.ppat.1004020.

5.XingLiu, WeiChen, QiangWang, LiLiChenWang* (2013): NegativeRegulationofTLRInflammatorySignalingbytheSUMO-deconjugatingEnzymeSENP6PLoSPathogens. Vol9(6): e1003480. doi: 10.1371/journal.ppat.1003480.

6.Yue-fengHuang, HengLiu, RuiGe, YiZhou, Xi-wenLouChenWang* (2012): UXT-V1facilitatestheformationofMAVSantiviralsignalsomeonmitochondriaJournalofImmunology. Vol188: 358-366.

7.He-XinShi, XingLiu, QiangWang, Pei-PeiTang, Xin-YiLiu, Yu-FeiShanChenWang*(2011): MitochondrialubiquitinligaseMARCH5promotesTLR7signalingbyattenuatingTANKactionPLOSPathogens. Vol7(5): e1002057. doi:10.1371/journal.ppat.1002057.

8.Xin-YiLiu, BoWei, He-XinShi, Yu-FeiShanChenWang* (2010): Tom70mediatesactivationofinterferonregulatoryfactor3onmitochondriaCellResearch.Vol20: 994-1011.

9.ShaogangSun, YujieTang, XiwenLou, LianhuiZhu, KaiYang, BianhongZhang, HexinShiandChenWang* (2007): UXTisanovelandessentialco-factorinNF-kBtranscriptionalenhancesomeJournalofCellBiology. Vol178: 231-244.

10.ChenWang, LiDeng, MeiHong, Giridhr. Akkaraju, Jun-IchiroInoue, ZhijianJ. Chen (2001): TAK1isaubiquitin-dependentkinaseofMKKandIKKNature.Vol412: 346-351.


(* CorrespondingAuthor通讯作者)