直聘教授-蒋晟

发布日期:2017-04-18浏览次数:1890

  蒋晟,博导、教授。1997年获中国药科大学学士学位,2000年获中科院上海有机化学研究所博士学位,2003-2007年在美国卫生部国立癌症研究所(NCI/NIH)从事博士后研究。曾任中国科学院广州生物医药与健康研究院百人计划研究员、博士生导师课题组组长。2017年以直聘教授引进到我校药学院药物化学系工作。兼任美国化学会会员,美国多肽学会会员,中国化学会会员,中国药学会高级会员。被聘为多个国际期刊如J. Med Chem.Bioorg. Med. Chem. Lett. Bioorg. Med. Chem.Eur. J. Med Chem.  J. Org. ChemOrganic Letters 等杂志特约审稿人。近年来共发表了68SCI论文包括国际核心杂志Chem. Commun., Organic Letters, Journal of Medicinal Chemistry等发表的一系列具有创新性的文章。兼任Scientific Reports、天然产物研究与开发等期刊编委。

  

代表性论文:

1.J. Bai, , C. Liao, D. Qin, Y. Liu, X. Qing, J. Chen, Z. Li, Z. Tu, S. Jiang.*Structure-Based Design of Potent Nicotinamide Phosphoribosyltransferase Inhibitors with Promising In Vitro and in Vivo Antitumor Activities. J. Med. Chem. 2016, 59, 5766-5779.

2.N. Ma, Y. Luo, Y. Wang, C. Liao, W.-C. Ye*, S. Jiang*.Selective histone deacetylase inhibitors with anticancer activity. Curr. Top. Med. Chem. 2016, 16, 415-426. 

3.Y. Jin, Y. Yao, L. Chen, X. Zhu, B. Jin, Y. Shen, J. Li, X. Du, Y. Lu, S. Jiang*, J. Pan*.Depletion of γ-catenin by Histone Deacetylase Inhibition Confers Elimination of CML Stem Cells in Combination with imatinib. Theranostics. 2016, 6, 1947-1962.

4.Y. Yao,Z. Tu,C. Liao, Z. Wang, S. Li, H. Yao, Z. Li,S. Jiang*.Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro Selectivity for Cancers Cells and in Vivo Antitumor Activities. J. Med. Chem. 2015, 58, 7672-7680.

5.Y. Yao,Z. Li, Y. Qiu, J. Su,S. Jiang*.Unprecedented reactions: from epichlorohydrin to epoxyglycidyl substituted divinyl ether and its conversion into epoxyglycidyl propargyl ether. ScientificReports. 2015,5, srep14231.

6.N. Ma, Y. Yao, B.-X. Zhao, Y. Wang, W.-C. Ye*, S. Jiang*.Total synthesis of securinega alkaloids (-)-norsecurinine, (-)-niruroidine and (-)-flueggine A. Chem. Commun. 2014, 50, 9284-9287. 

7.Y. Yao, C. Liao, Z. Li, Z. Wang, Q. Sun, C. Liu, Z. Tu*, S. Jiang*. Design, Synthesis, and Biological Evaluation of 1, 3-Disubstituted-Pyrazole Derivatives as New Class I and IIb Histone Deacetylase Inhibitors. Eur. J. Med. Chem. 2014, 86, 639-652.

8.X. Li, Z. Tu, H. Li, C. Liu, Z. Li, Q. Sun, Y. Yao, J. Liu, S. Jiang*.Biological evaluation of new largazole analogues: Alteration of macrocyclic scaffold with Click chemistry; ACS Medicinal Chemistry Letters. 2013, 4, 132-136.

9.Q. Xiao, Y. Liu, Y. Qiu, G. Zhou, C. Mao, Z. Li, Z.-J. Yao*, S. Jiang*. Potent Antitumor Mimetics of Annonaceous Acetogenins Embedded with an Aromatic Moiety in the Left Hydrocarbon Chain Part; J. Med. Chem.2011, 54, 525-533.

10.Y. Qiu, Y. Liu, K. Yang, W. Hong, Z. Li, Z. Wang, S. Jiang*. New Ligands That Promote Cross-Coupling Reactions between Aryl Halides and Unactivated Arenes. Org. Letters, 2011, 13, 3556-3559.

11.X. Zeng, B. Yin, Z. Hu, C. Liao, Z. Li, G. Zhou*, S. Jiang*.Total Synthesis and Biological Evaluation of Largazole and Derivatives with Promising Selectivity for Cancers Cells. Orgainc. Lett. 2010, 12, 1368-1371.